The DNAge Test
This diagnostic procedure was described by Steve Horvath
“What he calls the “epigenetic clock” is a bit like rust on a car. The DNA molecules experience chemical changes that could be interpreted as rust. So, as we age, things change on the molecule, and these changes are methylation, so by measuring the amount of “rust”, you can measure the age.
Another metaphor is that different locations on DNA are very much like hourglasses. Think of it like 353 different hourglasses in different locations, and I measure the height of sand in each to find an age estimate.”
A few days ago I asked to estimate my biological age:
Here it is:
“Your are 4 years younger than 83 % of people of your age”
What can be done that other people will achieve at least that?
Well the clock itself does not tell that. As I described only 16 % of the genome of a person has to do with longevity, around 85 % are due to biography.
It would be interesting to know what biographic lifestyle those people that are even younger than 100 % of people of their age.
I have asked Steve Horvath to explore this question from the data of people studied by his Zymo Company or from data of his other studies. Cant wait to get a result.
Further thoughts for aging:
Genome and environment in aging
There is recent evidence, that only 16% of the genome in human being are responsible for longevity in contrast to former data assuming about 30 %. This means that around 85 % have to do with environment, life style, education and biography.
That questions to me the research in the genome of long living animals like the whale bowl:
I mention particularly a sentence of the summary of this article:
“We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response.”
In essence, this means that genes involved in longevity are not a primary species specific inborn fact but the secondary evolutionary adaptation of these animals to their surrounding environment. Thermoregulation in this context is particularly relevant.
If so, the research in the naked mole by Calico may also be a wrong road to elaborate genes for longevity because in these animals longevity polymorphisms are not causative but they are secondary to their extremely harsh conditions in subterranean tunnels. They are protected from predators and the arid climate of the sub-Saharan region where they live.
The longevity of some human beings is also due to ambient environmental and life style conditions
although they differ largely:
Okinawa, Ovodda, Limone, Loma Linda.
Nevertheless their polymorphisms of longevity are the consequence and not the cause of it.
In summary it may be questioned if by gene engineering in the human genome or epigenome
longevity may be induced if lifestyle and environment continues , i.e. will they resist to unchanged
ambient conditions. It may well be possible that in the adult this will not work but if done on
embryos and stem cells there may be a chance to keep them working against senescence along
Currently I am preparing an article about aging and the “Dynamic Code” which will be ready to be published here within 2 weeks.
Meanwhile I wait for the result of the DNAge™ Epigenetic Aging Clock test by Steve Horvath.
Will I be older or younger than my biological age?
Write your guess to firstname.lastname@example.org.